Kassope or Cassope was an ancient Greek city in Epirus.
Kassope occupies a magnificent and remote site on a high platform overlooking the sea, the Ambracian Gulf and the fertile lands to the south, and with the slopes of the Zalongo mountain to the north.
It is considered one of the best remaining examples of a city built on a rectilinear street grid of a Hippodamian plan in Greece.
The first settlements on the site are from the Paleolithic. However the city of Kassope was founded in the middle of the 4th century BC as the capital of the Kassopaeans, a sub-tribe of the Thesprotians. It belonged to the Aetolian League. The city flourished in the 3rd century BC, when large public buildings were built.
The ruins of Kassope were visited and described by William Martin Leake in the early 19th century.
Kassope has remarkable monuments which dominate the plateau.