The Battle of Bicocca or La Bicocca was fought on 27 April 1522, during the Italian War of 1521–26. A combined French and Venetian force under Odet de Foix, Vicomte de Lautrec, was decisively defeated by a Imperial–Spanish and Papal army under the overall command of Prospero Colonna. Lautrec then withdrew from Lombardy, leaving the Duchy of Milan in Imperial hands.
At the start of the war in 1521, Holy Roman Emperor Charles V and Pope Leo X moved jointly against the Duchy of Milan, the principal French possession in Lombardy. A large Papal force under Federico II Gonzaga, Duke of Mantua, together with Spanish troops from Naples and some smaller Italian contingents, concentrated near Mantua.
Colonna had meanwhile relocated to a formidable new position: the manor park of Bicocca, about four miles north of Milan.